CCTRN - In the News

Click below to hear about the first PACE patient at IUHealth:

• IUHealth PACE News

Click below to hear about CCTRN at IUHealth:

• CCTRN at IUHealth

Click the link below to watch an Emmy award-winning video on the stem cell program at University of Miami:

• University of Miami stem cell program

Click below to read the TIME results press release from the National Heart, Lung and Blood Institute (NHLBI):

• NHLBI TIME Press Release

Click below to read the FOCUS results press release from the Journal of the American Medical Association (JAMA):

• JAMA FOCUS Press Release

Click below to read the LateTIME results press release from the National Heart, Lung, and Blood Institute (NHLBI):

• NHLBI LateTIME Press Release

Click the play arrow below to watch these two news stories on a CCTRN LateTIME patient treated in Florida:

Click below to read about a LateTIME patient treated in Tampa, Florida.

• http://www.tampabay.com/news/health/study-hopes-to-use-patients-own-stem-cells-to-mend-broken-hearts/1041081

Click below to hear a podcast with CCTRN investigators on the Minnesota Public Radio (MPR) Morning Show with Carrie Miller.

• http://minnesota.publicradio.org/display/web/2010/01/15/midmorning1/

CCTRN Publications

Outcome Papers

• One-Year Follow-up of Intracoronary Stem Cell Delivery on Left Ventricular Function Following ST-Elevation Myocardial Infarction

Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, and Stephen G. Ellis.   Journal of the American Medical Association (2014): Volume 311, Issue 3, pgs. 301-302.

• Effect of Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial

Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Journal of the American Medical Association (2012): Volume 308, Issue 22, pgs. 2380-2389.

• Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Ischemic Heart Failure: The FOCUS-CCTRN Trial

Emerson C. Perin, James T. Willerson, Carl J. Pepine, Timothy D. Henry, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Journal of the American Medical Association (2012): Volume 307, Issue 16, pgs. 1717-1726.

• Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: the LateTIME Randomized Trial

Jay H. Traverse, Timothy D. Henry, Stephen G. Ellis, Carl J. Pepine, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Journal of the American Medical Association (2011): Volume 306, Issue 19, pgs. 2110-2119.

Design Papers

• Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells.

Emerson C. Perin, Michael Murphy, John P. Cooke, Lem Moyé, Timothy D. Henry, Judy Bettencourt, Amir Gahremanpour, Nicholas Leeper, R. David Anderson, William R. Hiatt, Joao A. Lima, Bharath Venkatesh, Shelly L. Sayre, Rachel W. Vojvodic, Doris A. Taylor, Ray F. Ebert, and Alan T. Hirsch for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J. 2014 Nov; 168(5):667-673.e2.

• Rationale and Design for TIME: A Phase-II, Randomized, Double-Blind, Placebo-Controlled Pilot Trial Evaluating the Safety and Effect of Timing of Administration of Bone Marrow Mononuclear Cells Following Acute Myocardial Infarction

Jay H. Traverse, Timothy D. Henry, Douglas E. Vaughan, Stephen G. Ellis, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  American Heart Journal (2009): Volume 158, Issue 3, pgs. 356-363.

• A Phase-II, Randomized, Placebo-Controlled, Double-Blind Pilot Trial Evaluating the Safety and Effect of Administration of Bone Marrow Mononuclear Cells Two to Three Weeks Following Acute Myocardial Infarction: Rationale and Design for LateTIME

Jay H Traverse, Timothy D Henry, Douglas E. Vaughan, Stephen G. Ellis, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Texas Heart Institute Journal (2010): Volume 37, Issue 4, pgs. 412-420.

• Rationale and Design for the Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells for Patients with Chronic Ischemic Heart Disease and Left Ventricular Dysfunction Trial (FOCUS)

James T. Willerson, Emerson C. Perin, Stephen G. Ellis, Carl J. Pepine, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   American Heart Journal (2010): Volume 160, Issue 2, pgs. 215-223.

• Developing Mechanistic Insights into Cardiovascular Cell Therapy - Cardiovascular Cell Therapy Research Network (CCTRN) Biorepository Core Laboratory Rationale 

Claudia Zierold, Marjorie Carlson, Udo Obodo, Elizabeth Wise, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  American Heart Journal (2011): Volume 162, Issue 6, pgs. 973-980.

Other Papers

• Bone Marrow Characteristics Associated with Changes in Infarct Size After STEMI: A Biorepository Evaluation from the CCTRN TIME Trial.

Robert C. Schutt, Barry H. Trachtenberg, John P. Cooke, Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, Emerson C. Perin, Stephen G. Ellis, David X. M. Zhao, Aruni Bhatnagar, Brian H. Johnstone, Dejian Lai, Micheline Resende, Ray F. Ebert, Joseph C. Wu, Shelly L. Sayre, Aaron Orozco, Claudia Zierold, Robert D. Simari, Lem Moyé, Christopher R. Cogle, and Doris A. Taylor for the Cardiovascular Cell Therapy Research Network (CCTRN). Circulation Research: Available online November 18, 2014.

• A Detailed Analysis of Bone Marrow from Patients with Ischemic Heart Disease and Left Ventricular Dysfunction: BM CD34, CD11b, and Clonogenic Capacity as Biomarkers for Clinical Outcomes

Christopher R. Cogle, Elizabeth Wise, Amy M. Meacham, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Circulation Research (2014): Volume 115, Issue 10, pgs. 867-874.

• DAMASCENE and Meta-Ecological Research: A Bridge Too Far

Moyé, Lem.  Circulation Research (2014): Volume 115, Issue 5, pgs. 484-487.

• Clinical Monitoring in a Federally Funded Environment: Evolution and Opportunities in the Cardiovascular Cell Therapy Research Network 

Sibi R. Mathew, Kristen D. Lucas, Shelly L. Sayre, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  The Monitor (February 2014): pgs. 31-36.

• Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis

Ronak Delewi, Alexander Hirsch, Jan G. Tijssen, et al.  European Heart Journal (2014): Volume 35, Issue 15, pgs. 989-998.

• Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction: A Perspective from the CCTRN 

Robert D. Simari, Carl J. Pepine, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Circulation Research (2014): Volume 114, Issue 10, pgs. 1564-1568.

• Mesenchymal Precursor Cells as Adjunctive Therapy in Recipients of Contemporary Left Ventricular Assist Devices 

Deborah D. Ascheim, Annetine C. Gelijns, Daniel Goldstein, et al.   Circulation (2014) Volume 129, Issue 22, pgs. 2287-2296.

• Recruiting for Acute Myocardial Infarction Cell Therapy Trials: Challenges and Best Practices 

Rachel E. Olson, Rachel W. Vojvodic, Judy Bettencourt, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Clinical Researcher (August 2014): pgs. 71-77.

• Phase II Clinical Research Design in Cardiology Learning the Right Lessons Too Well: Observations and Recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN) 

Joshua M. Hare, Roberto Bolli, John P. Cooke, David J. Gordon et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Circulation (2013): Volume 127, Issue 15, pgs. 1630-1635.

• A Critical Analysis of Clinical Outcomes Reported in Stem Cell Trials for Acute Myocardial Infarction: Some Thoughts for Design of Future Trials 

Anita D. Szady, Carl J. Pepine, Shreela V. Sharma, Christopher R. Cogle, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Current Atherosclerosis Reports (2013): Volume 15, Issue 8, pgs. 341-013-0341-9.

• Implementation of Cardiovascular Cell Therapy Network trials – challenges, innovation and lessons learned from experience in the CCTRN 

Ki E. Park, Lemuel A. Moyé, Timothy D. Henry, Emerson C. Perin, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Expert Reviews in Cardiovascular Therapy (2013): Volume 11, Issue 11, pgs. 1495-1502.

• Factors affecting the Turnaround Time for Manufacturing, Testing and Release of Cellular Therapy Products prepared at Multiple Sites in support of Multicenter Cardiovascular Regenerative Medicine Protocols – a Cardiovascular Cell Therapy Research Network (CCTRN) Study 

Sara J. Richman, Adrian P. Gee, David H. McKenna, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Transfusion (2012): Volume 52, Issue 10, pgs. 2225-2233.

• Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network (CCTRN) 

Martin Rodriguez-Porcel, Marvin W. Kronenberg, Timothy D. Henry, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Journal of the American College of Cardiology Cardiovascular Imaging (2012): Volume 5, Issue 5, pgs. 559-565.

• Quantification of Myocardial Segmental Function in Acute and Chronic Ischemic Heart Disease and Implications for Cardiovascular Cell Therapy Trials: A Review from the NHLBI-Cardiovascular Cell Therapy Research Network 

John Petersen, John R. Forder, James D. Thomas, Lemuel A. Moyé, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).   Journal of the American College of Cardiology Cardiovascular Imaging (2011): Volume 4, Issue 6, pgs. 671-679.

• Oversight and Management of a Cell Therapy Clinical Trial Network: Experience and Lessons Learned 

Lemuel A. Moyé, Shelly L. Sayre, Lynette Westbrook, Beth C. Jorgenson, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN).  Contemporary Clinical Trials (2011): Volume 32, Issue 5, pgs. 614-619.

• Cell Therapy and Satellite Centers: The Cardiovascular Cell Therapy Research Network Experience 

Lemuel A. Moyé, Timothy D. Henry, Ken W. Baran, Judy L. Bettencourt, et al for the Cardiovascular Cell Therapy Research Network (CCTRN).  Contemporary Clinical Trials (2011): Volume 32, Issue 6, pgs. 841-847.

• Development of a Network to Test Strategies in Cardiovascular Cell Delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN)

Robert D. Simari, Lemuel A. Moyé, Sonia I. Skarlatos, Stephen G. Ellis, et al.   Journal of Cardiovascular Translational Research (2010): Volume 3, Issue 1, pgs. 30-36.

• Multicenter Cell Processing for Cardiovascular Regenerative Medicine Applications - The Cardiovascular Cell Therapy Research Network (CCTRN) Experience 

Adrian P. Gee, Sara Richman, April Durett, David McKenna, et al.  Cytotherapy (2010): Volume 12, Issue 5, pgs. 684-691.