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Cryotherapy for Retinopathy of Prematurity Study (CRYO-ROP)

cryorop.gifA randomized multicenter study in 23 centers enrolling 4,099 infants in a natural history study with a randomized clinical trial that determined the safety and efficacy of cryotherapy of the retina in the treatment of retinopathy of prematurity in 291 premature infants.

Sponsored by the National Eye Institute (NEI); 1985–2003 ($4,534,242).

Final Papers

Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmological outcomes at 10 years. Arch Ophthalmol 2001;119:1110-1118.

Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: One-year outcome — structure and function. Arch Ophthalmol 1990;108:1408-1416.

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